The number and frequency of sessions are determined by the severity, duration and nature of the condition. Significant improvement is usually observed over a course of 4 to 6 sessions. However, to maintain and enhance the results additional maintenance sessions at regular intervals are recommended. These are individually tailed to the progression of the condition and the needs of the body.

Treatment is effectively combined with other methods, such as kinesiotherapy to improve range of motion, neuromuscular strengthening exercises to enhance stability and movement control, and a structured stretching program to reduce muscle tension and relieve stress on tendons, as well as organic interventions aimed at modifying activities and avoiding aggravating movements. All instructions are individually designed according to the patient's needs and the characteristics of the dysfunction, in order to achieve optimal rehabilitation. A holistic approach leads to more stable and long-lasting outcomes.

The key difference between iliotibial band syndrome (ITBS) and other causes of lateral knee pain—such as meniscal injury or degenerative osteoarthritis—is that ITBS does not involve the knee joint itself, but rather the surrounding soft tissues. In ITBS, pain typically occurs during physical activity and subsides with rest, whereas in other conditions, pain may be more constant. Proper diagnosis and differential diagnosis require clinical examination and, in some cases, imaging tests.

Iliotibial band syndrome (ITBS) is more common in individuals who engage in high-intensity and repetitive physical activities, such as long-distance runners, cyclists, and hikers. The risk is also higher in people with anatomical abnormalities such as flat feet, uneven leg length, or excessive internal rotation of the femur, as well as in those with muscle imbalances or poor flexibility in the hip and gluteal region. A sudden increase in exercise intensity or duration without proper preparation is also a significant risk factor.